so I've got a close friend calling me in the middle of night saying what is wrong with her life when she got almost-everything but still haven't figured the 'it thing' in her life that is still missing.

umph, well, that is not that easy for me to say when each day, everyday that hole is there, for me, too.
Now, what is wrong?

Surrounded by beautiful family, supportive friends, almost-good job,
and still, what is wrong ?